Convenient, ready to use filtration devices in 96-well microplate format. Each well has a filter individually sealed into the base, below which runs a unique drip director to accurately deliver the filtrate into the receiving well of an accessory microplate positioned underneath, with no splashing or cross contamination. A wide range of filter media are offered to allow compatibility with a variety of sample types. Plates are manufactured in polystyrene (PS) for general use with biological samples. 800µl filtration plates are used for high throughput screening sample preparation and clean up. Typical applications include cell-based immunoassay, nucleic acid isolation, sterile filtration of biological samples and compound library generation using parallel synthesis procedures.